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Common causes of infertility of females include: ovulation problems (e.g. polycystic ovarian syndrome, PCOS, the leading reason why women present to fertility clinics due to anovulatory infertility.[58]) tubal blockage pelvic inflammatory disease caused by infections like tuberculosis age-related factors uterine problems previous tubal ligation endometriosis advanced maternal age immune infertility Males[edit] The main cause of male infertility is low semen quality. This is done for men with very low or no sperm in their semen. Role of Semen Analysis in Subfertile Couples. (PDF, 250 KB) Fertility and Sterility, 2010. Chemotherapy: Some chemotherapy drugs can result in ovarian failure.

Etiology of Sterility Causes of sterility can be manifold and diverse. In GIFT, the sperm and eggs are mixed together before a doctor inserts them. 34 Although intrauterine insemination has been shown to be equally effective as timed intercourse in unstimulated cycles, there is a modest increase in live birth rates when combined with ovarian stimulation. Many more couples, however, experience involuntary childlessness for at least one year: estimates range from 12% to 28%.[4] Male infertility is responsible for 20–30% of infertility cases, while 20–35% are due to female infertility, and 25–40% are due to combined problems in both parts.[2][5] In 10–20% of cases, no cause is found.[5] The most common cause of female infertility is ovulatory problems, which generally manifest themselves by sparse or absent menstrual periods.[6] Male infertility is most commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity.[7] Women who are fertile experience a natural period of fertility before and during ovulation, and they are naturally infertile for the rest of the menstrual cycle. Worldwide, 8 to 12 percent of couples experience fertility problems.

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Several studies have reported different causes of infertility [7-9]. One reported method to induce estrus in cats is FSH at 2 mg/cat, IM, once daily until signs of estrus appear (not administered for >5 days). They don’t have any reason to suspect they may have infertility until they start trying to conceive. Infertility caused by DNA defects on the Y chromosome is passed on from father to son. Metformin (Glucophage) is another type of medication that may help you ovulate normally if you have insulin resistance or PCOS (polycystic ovarian syndrome). ICSI with Epididymal and Testicular Sperm Retrieval. (PDF, 1 MB) Male Sterility and Motility Disorders: Etiological Factors and Treatment, 1998.

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Recent Advances in Male Reproductive Surgery. (PDF, 10 MB) Chapter 13 from Annual Progress in Reproductive Medicine, 1993. Treatment of Renal Trauma by Angiographic Injection of Autologous Clot. (PDF, 422 KB) British Journal of Urology, 1974. Management of ejaculatory failure: - Can be of great value as in retrograde ejaculation. Other causes may include: Genetic factors: A man should have an X and Y chromosome. Recombination Between Palindromes P5 and P1 on the HUman Y Chromosome Causes Massive Deletions and Spermatogenic Failure. (PDF, 786 KB) The American Journal of Human Genetics, 2002. In some women, and especially with age, the membrane becomes harder.

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Pregnancies after Testicular Sperm Extraction and Intracytoplasmic Sperm Injection in Non-obstructive Azoospermia. (PDF, 3 MB) Human Reproduction, 1995. IVF and other fertility treatments have resulted in an increase in multiple births, provoking ethical analysis because of the link between multiple pregnancies, premature birth, and a host of health problems. These endometrial cells can extend as far as the outside of the fallopian tubes, the ovaries and the bladder. The sperm must provide the zygote with DNA, centrioles, and activation factor for the embryo to develop.