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Sexually transmitted infections (STIs): Chlamydia can damage the fallopian tubes in a woman and cause inflammation in a man's scrotum. Ovulation disorders can be due to: Premature ovarian failure: The ovaries stop working before the age of 40 years. The Prevention of Acute Tubular Necrosis in Renal Transplantation by Chronic Salt Loading of the Recipient. (PDF, 627 KB) ANZ Journal of Surgery, 1974. Antibodies that are bound to sperm decrease the sperm’s ability to penetrate the cervical mucus and bind to the zona pellucida. For example, endometriosis can cause infertility with the growth of endometrial tissue in the Fallopian tubes or around the ovaries.

A combination of these factors leads to infertility 20 to 30 percent of the time. It can also help if a man has severe erectile dysfunction. Female and male factors are equally responsible for infertility, about 30% to 40% each, and in 20% of the cases, there is a combination of both. A woman with a suspicion of chronic anovulation most probably due to polycystic ovary (PCO) syndrome, as there is a long history of irregular cycles and clinical presentation with hirsutism, her serum levels of testosterone hormone, sex hormone binding globulin (SHBG), dihydroepiandrostenedione (DHEA), dihydroepiandrostenedione-sulfate (DHEAS) and prolactin should be evaluated to prove the provisional diagnosis and to detect the source of excess androgens. Hystersalpingography (HSG): - usually after failed successive cycles of ovulation induction, and in some centres after failed IUI. - good predictive but requires expertise.

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In such circumstances, it is recommended not to prescribe any medication until all basic investigations are done and its results received. Microsurgical Solutions to Male Infertility. (PDF, 2 MB) Contemporary OB/GYN, 2005. ARTICLES FROM THE 2000s Evaluation and Treatment of Male Infertility. (PDF, 17 MB) Clinical Obstetrics and Gynecology, 2000. In 1978, the first baby was born as a result of IVF. Options for treatment may include: Treatment with antibiotics, in cases of infection Surgical correction, in order to remove a varicocele, reverse a vasectomy, or repair a duct obstruction Medications or fertility drugs to improve sperm production In cases where the above treatments are unsuccessful, or when the cause of male infertility is unknown or untreatable, IUI treatment or IVF treatment may be suggested. Distribution of Spermatogenesis in the Testicles of Azoospermic Men: The Presence of Spermatids in the Testes of Men with Germinal Failure. (PDF, 295 KB) Human Reproduction, 1997.

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The administration of hMG and its derivatives should be under the direct supervision of a reproductive endocrinologist. As they respond to hormones the same way as they would do in the uterus, that is by growing and shedding cyclically, endometriosis can cause both fallopian tube and ovarian scarring. Exercise: Both too much and too little exercise can lead to fertility problems.

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Other factors that can affect a woman's chances of conceiving include being overweight or underweight,[56] or her age as female fertility declines after the age of 30.[57] Sometimes it can be a combination of factors, and sometimes a clear cause is never established. The feelings experienced by the infertile couples include depression, grief, guilt, shame, and inadequacy with social isolation. Investigations Infertile couples are usually adviced to start their investigations after 12 months of trying to conceive or after 6 months if the female partner is more than 35 years old or immediately if there is an obvious cause for their infertility or subfertility [16]. Financing fertility treatment can also be costly, but there are programs that can help with this.Infertility is the inability of a person, animal or plant to reproduce by natural means. Medical conditions Some medical conditions can affect fertility. Other factors that can affect a woman's chances of conceiving include being overweight or underweight,[56] or her age as female fertility declines after the age of 30.[57] Sometimes it can be a combination of factors, and sometimes a clear cause is never established. Risk factors for both men and women are the same and these include age, stress, being underweight or overweight, diet, smoking, alcohol and drugs.