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If natural selection is the primary error correction mechanism that prevents random mutations on the Y chromosome, then fertility treatments for men with abnormal sperm (in particular ICSI) only defer the underlying problem to the next male generation. Microsurgery of the Male Genitalia for Infertility. (PDF, 8 MB) Chapter 59 from Reconstructive Urologic Surgery, 1994.

The most commonly prescribed injections that stimulate the ovary are called gonadotropins. Ovulation induction in polycystic ovary syndrome [published corrections appear in J Obstet Gynaecol Can. As well as generally causing pelvic and menstrual pain, it is estimated that around 40% of women faced with difficulties getting pregnant have endometriosis. Bilateral anorchia (vanishing testes syndrome) Patients have a normal male karyotype (46, XY) but are born without testis bilaterally. Sterility can affect both men and women, with the cause involving either one or both parties.

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Gracia CR, Sammel MD, Coutifaris C, Guzick DS, Barnhart KT. The following is a list of hormonal disorders which can disrupt male infertility: Hyperprolactinemia: Elevated prolactin--a hormone associated with nursing mothers, is found in 10 to 40 percent of infertile males.  Mild elevation of prolactin levels produces no symptoms, but greater elevations of the hormone reduces sperm production, reduces libido and may cause impotence.  This condition responds well to the drug Parlodel (bromocriptine). Fertility Evaluation: Obstetric and Gynecological History The obstetric and gynecological history should include: Reproductive history (children, mode of delivery, prematurity, stillbirth, extrauterine pregnancy, spontaneous and induced abortion, fertility and infertility in earlier relationships). Gonadotropin-releasing hormone (Gn-RH) analogs: These can help women who ovulate too early—before the lead follicle is mature—during hmG treatment.

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Intracytoplasmic Sperm Injection Today: A Personal Review. (PDF, 5 MB) Human Reproduction, 1998. London, United Kingdom: National Institute for Health and Clinical Excellence (NICE); February 2013:1–63. (Clinical guideline no. Estrous cycle abnormalities can cause infertility.

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Vasectomy and its Microsurgical Reversal. (PDF, 17 MB) Urologic Clinics of North America, 1978. Fertility: assessment and treatment for people with fertility problems. The dynamics of stress in fertile and infertile couples. Earn up to 6 CME credits per issue.     To see the full article, log in or purchase access. Dealing with Fertility Problems After Vasectomy Reversal. (PDF, 7 MB) Contemporary OB/GYN, 1978. Role of Epididymis in Sperm Maturation. (PDF, 3 MB) Urology, 1989. Ideally, the test should be performed at least twice to confirm results.


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