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Several studies have demonstrated that an increase in BMI is correlated with a decrease in sperm concentration, a decrease in motility and an increase DNA damage in sperm. Leptin is a hormone associated with numerous effects including appetite control, inflammation, and decreased insulin secretion, according to many studies.

Most typical are decreased libido, erectile dysfunction, orgasmic dysfunction, and ejaculatory dysfunction. This is taken from the vaginal vault as well as from the cervical canal.

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Diagnostic evaluation of the infertile female: a committee opinion. Smoking: Smoking significantly increases the risk of infertility in both men and women, and it may undermine the effects of fertility treatment. Some causes, such as hyperprolactinemia, are reversible with proper treatment. When one year of sexual relationships without birth control measures has not lead to a pregnancy. Primary infertility When a woman is unable to ever bear a child, either due to the inability to become pregnant or the inability to carry a pregnancy to a live birth she would be classified as having primary infertility. Ovarian Transplantation in a Series of Monozygotic Twins Discordant for Ovarian Failure. (PDF, 188 KB) The New England Journal of Medicine, 2007.

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Thyroid problems: An overactive or underactive thyroid gland can lead to a hormonal imbalance. Microsurgical Reversal of Tubal Sterilization: Factors Affecting Pregnancy Rate, with Long-term Follow-up. (PDF, 2 MB) Obstetrics & Gynecology, 1984. This is caused by hormonal issues like thyroid hypo- or hyperfunction, hyperprolactinemia, or polycystic ovarian syndrome (PCOS) — all of which can lead to infertility.  Absence of periods: Temporary life stress or overexercising may cause you to occasionally skip a period.

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Luciano AA, Peluso J, Koch EI, Maier D, Kuslis S, Davison E. Medical conditions Some medical conditions can affect fertility. Men with Infertility Caused by AZFc Deletion can Produce Sons by Intracytoplasmic Sperm Injection, but are Likely to Transmit the Deletion and Infertility. (PDF, 102 KB) Human Reproduction, 1999. Vasectomy and its Microsurgical Reversal. (PDF, 17 MB) Urologic Clinics of North America, 1978. About 85% of couples will have had a pregnancy by that point. “If they are over 30, they should seek evaluation after six months.” Continued Common causes of male infertility The “male factor” contributes to infertility around half the time, and about one third of the time, it's the main cause of infertility. Clean, Intermittent Self-catheterization in the Treatment of Urinary Tract Disease. (PDF, 2 MB) The Journal of Urology, 1972. Blood, urine, and imaging tests can be done to discover why you are having trouble getting pregnant. The main approach to correcting or removing these uterine abnormalities is by hysteroscopy, a surgical method by which a narrow scope with a camera is placed within the uterine cavity. Sertoli cells also secrete inhibin, which provides negative feedback on the hypothalamus, and androgen-binding protein, which helps modulate androgen activity in the seminiferous tubules. Ejaculation disorders Ejaculation disorders include premature ejaculation, anejaculation (the failure to ejaculate), and retrograde ejaculation, which is when semen enters the bladder during orgasm instead of coming out the tip of the penis.