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8) Unexplained/other: Sometimes a full evaluation does not reveal the cause of infertility. A doctor injects sperm directly into the egg in a dish and then places it into your uterus. A Series of Monozygotic Twins Discordant for Ovarian Failure: Ovary Transplantation (Cortical versus Microvascular) and Crypreservation. (PDF, 791 KB) Human Reproduction, 2008.

Abnormality in any of those regions may indicate abnormal sperm function and compromise the ability of sperm to fertilize the egg. Large submucosal uterine fibroids may make the uterus' cavity bigger, increasing the distance the sperm has to travel. Ageing ” population ... chronic & degenerative diseases Multiple health problems are common in elderly people THE ... Patients are at increased risk of infertility, even if the testicle is brought down into the scrotum, as the testicle itself may be inherently abnormal.

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However, intercourse 3 times a week results in a probability of conception around 50% within 6 months. Less common factors The following other factors may also be responsible for infertility in a smaller proportion of cases: • Genetic abnormalities within eggs, sperm or both • An abnormal uterine cavity, including the presence of fibroids or polyps • Immunological infertility, whereby either the male or female partner produces anti-bodies against sperm cells or implantation of an embryo • Abnormal cervical mucus which hinders the passage of sperm to the uterus and fallopian tubes Unexplained infertility Even when investigations have been extensive, some couples will have no reason with which to explain their infertility. Endometriosis is usually more common in women in their mid-twenties and older, especially when postponed childbirth has taken place.[55] Another major cause of infertility in women may be the inability to ovulate. Clomiphene citrate (Clomid, Serophene) The chemical formula for clomiphene citrate (CC) is 2-[p -(2-chloro-1,2-difhenylvinyl) phenoxy] triethylamine dihydrogen citrate. Recent Advances in Male Reproductive Surgery. (PDF, 10 MB) Chapter 13 from Annual Progress in Reproductive Medicine, 1993. After injection of the sperm, the patient remains in the recumbent position for 10-15 minutes.

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Ovulation should be documented by serum progesterone level measurement at cycle day 21. Varicocele A varicocele is a dilation of the veins of the pampiniform plexus of the scrotum. Transrectal ultrasonography (TRUS) may reveal enlarged seminal vesicles, but this is not universal. Debate over whether health insurance companies (e.g. in the US) should be required to cover infertility treatment. The cystic fibrosis transmembrane regulator (CFTR) protein plays a role in mesonephric duct development during early fetal life, so these patients may also have urinary tract abnormalities. It is usually not the natural state of a healthy adult, except notably among certain eusocial species (mostly haplodiploid insects).

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Chemotherapy: Some chemotherapy drugs can result in ovarian failure. Intracytoplasmic Sperm Injection Today: A Personal Review. (PDF, 5 MB) Human Reproduction, 1998. A failure of GnRH neurons to migrate to the proper location in the hypothalamus has been implicated. Moderate ovarian hyperstimulation syndrome is characterized by ovarian enlargement (5-12 cm in diameter) moderate ascites, nausea, vomiting, abdominal discomfort, and weight gain greater than 10 lb. Hysterosalpingo-contrast-ultrasonography - TVS scan during which air and saline or a solution of D-galactose is infused into the uterine cavity and observed to flow along the fallopian tubes. - Requires more expertise. - Less invasive. Sterility is an emotional journey for the couple trying to become pregnant, and feelings of anger, guilt, and depression are not uncommon. 50% are female causes with 25% being due to anovulation and 25% tubal problems/other.[74] In Sweden, approximately 10% of couples wanting children are infertile.[75] In approximately one third of these cases the man is the factor, in one third the woman is the factor, and in the remaining third the infertility is a product of factors on both parts. As the rate of getting spontaneous pregnancy among infertile or subfertile couples is lower than that among normal fertile population, it is recommended to carry out the following diagnostic, evidence-based, work-up to detect any hidden treatable cause.


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