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A woman of reproductive age who is using artificial insemination to conceive (with either partner or donor sperm) after 6 failed trials. Consider earlier referral to infertility specialists where: - the woman is aged 36 years or over. - there is a known clinical cause of infertility or a history of predisposing factors for infertility. - treatment is planned that may result in infertility (such as treatment for cancer). - People who are concerned about their fertility and who are known to have chronic viral infections such as hepatitis B, hepatitis C or HIV. These may be purchased over the counter and allow couples to predict the most fertile days in the cycle. However, a complete blockage of the ovaries is rarely a cause of infertility.

A failure of GnRH neurons to migrate to the proper location in the hypothalamus has been implicated. Thoracentesis is rarely indicated in cases of pleural effusion.

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Key to the diagnosis of male infertility is a semen analysis, which assesses primarily sperm numbers, sperm movement and sperm form. Excess alcohol consumption: This may lower male fertility. Infertility caused by DNA defects on the Y chromosome is passed on from father to son. Anabolic steroids: Popular with bodybuilders and athletes, long-term use can seriously reduce sperm count and mobility.

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Results of one study investigating a cohort of 315 men revealed changes within the hinge region of SF-1 and no rare allelic variants in fertile control men. Instruments can be introduced through the hysteroscope, allowing the surgeon to remove or correct any anatomic abnormalities. Tumors Cancers and nonmalignant tumors can affect the male reproductive organs directly, through the glands that release hormones related to reproduction, such as the pituitary gland, or through unknown causes. A doctor or WHNP takes a medical history and gives a physical examination. Reversal of Vasectomy and the Treatment of Male Infertility. (PDF, 4 MB) Urologic Clinics of North America, 1981.

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Zygote Intrafallopian Transfer (ZIFT) Zygote Intrafallopian Transfer (ZIFT) is another variation of IVF. 18  If the semen analysis result is abnormal, further evaluation is indicated (Table 36–8,10,19,20). The Three-kidney Rat Model. (PDF, 2 MB) Investigative Urology, 1974. Problems in the uterus or fallopian tubes can prevent the egg from traveling from the ovary to the uterus, or womb. The sperm must provide the zygote with DNA, centrioles, and activation factor for the embryo to develop.