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Get Permissions Email Alerts Don't miss a single issue. Article Sections Infertility is defined as the inability to achieve pregnancy after one year of regular, unprotected intercourse. Continued First, sperm are collected either from ejaculated semen or by a needle from the testicle. Cervical surgery can also sometimes cause scarring or shorten the neck of the womb (the cervix). Prolactinoma A prolactin-secreting adenoma is the most common functional pituitary tumor. Medications, treatments, and drugs Some drugs can affect fertility in a woman.

Removal of polyps by the minimally invasive procedure hysteroscopy is associated with a doubling of pregnancy rate. Chemotherapy: Some chemotherapy drugs can result in ovarian failure. Women receiving fertility treatment have a slightly higher risk of an ectopic pregnancy. Around one third of couples have difficulty conceiving due to a low sperm count. Studies on Testicular Biopsies from Vasectomized Men. (PDF, 18 MB) Chapter 21 from Vasectomy: Immunologic and Pathophysiologic Effects in Animals and Man, 1979.

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RE: The Impalpable Testis: A Rational Approach to Management. (PDF, 389 KB) The Journal of Urology, 1979. The most common disorders impacting ovulation include polycystic ovary syndrome (PCOS), hypogonadotropic hypogonadism (from signaling problems in the brain), and ovarian insufficiency (from problems of the ovary).

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Intracytoplasmic Sperm Injection and Infertility. (PDF, 53 KB) Nature Genetics, 2001. Renal Echinococcus. (PDF, 1 MB) The Journal of Urology, 1972. Symptoms of hormonal imbalance: Sudden weight gain, hair loss, constant fatigue, edema, headaches, nipple discharge, facial hair, or severe acne are all signs of possible hormonal disorders. Thyroid dysfunction can halt ovulation by upsetting the balance of the body’s natural reproductive hormones. Also searched were the Cochrane database, the National Guideline Clearinghouse database, Dynamed, and Essential Evidence Plus.

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Normal Pregnancies Resulting from Testicular Sperm Extraction and Intracytoplasmic Sperm Injection for Azoospermia Due to Maturation Arrest. (PDF, 6 MB) Fertility and Sterility, 1996. Pelvic inflammatory disease Pelvic inflammatory disease (PID) is an infection of the upper female genital tract, which includes the womb, fallopian tubes and ovaries. The testicle contains the Leydig cells and the Sertoli cells and is covered by the tunica albuginea, which also provides septae that divide it into approximately 200-350 pyramids (see image below). Come and meet us to find out more about how we can help you. The other cases are caused by a mixture of male and female problems or by unknown problems. Kidney Transplantation in Inbred Rats. (PDF, 6 MB) The American Journal of Surgery, 1973. Seminoma Discovered in Two Males Undergoing Successful Testicular Sperm Extraction for Intracytoplasmic Sperm Injection. (PDF, 807 KB) Human Reproduction, 1995. Radiation therapy While Leydig cells are relatively radioresistant because of their low rate of cell division, the Sertoli and germ cells are extremely radiosensitive. Diverse Spermatogenic Defects in Humans Caused by Y Chromosome Deletions Encompassing a Novel RNA-binding Protein Gene. (PDF, 2 MB) Human Reproduction, 1996. Histology reveals seminiferous tubules lined by Sertoli cells and a normal interstitium, although no germ cells are present.