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Antibodies that attack sperm Anti-sperm antibodies are immune system cells that mistakenly identify sperm as harmful invaders and attempt to eliminate them. Ovulation disorders can be due to: Premature ovarian failure: The ovaries stop working before the age of 40 years. Chemotherapy: Some chemotherapy drugs can result in ovarian failure. Intrauterine insemination (IUI.)At the time of ovulation, sperm are injected directly up into the uterus. Pregnancy Caused by Sperm from Vasa Efferentia. (PDF, 1 MB) Fertility and Sterility, 1988. Undescended testicles During fetal development one or both testicles may fail to descend from the abdomen into the sac that normally contains the testicles.

Abdominal myomectomy is a surgical procedure performed through a very low horizontal abdominal incision allowing access to the uterus for removal of fibroids. Checking the woman’s fallopian tubes to make sure they are not blocked. Ovulation problems can be a result of:  polycystic ovary syndrome (PCOS) thyroid problems – both an overactive thyroid gland and an underactive thyroid gland can prevent ovulation premature ovarian failure – where a woman's ovaries stop working before the age of 40 Scarring from surgery Pelvic surgery can damage and scar the fallopian tubes, which link the ovaries to the womb. Mannitol Induced Central Nervous System Toxicity in Renal Failure. (PDF, 4 MB) Investigative Urology, 1972. For one, don’t do things to hurt your chances to have viable sperm — marijuana, cocaine, tobacco, and more than two alcoholic drinks a day harm sperm production, says Ross.

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MESA or TESA? (PDF, 115 KB) Human Reproduction, 1996. Exposure to toxic agents can occur from occupational hazards or contaminated air, water, food supply or other exposures.

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Several days later, embryos -- or fertilized eggs -- get put back into your uterus with a device called an intrauterine insemination catheter. Fertility may improve after adopting a gluten-free diet.Infertility: Introduction Infertility is a significant social and medical problem affecting couples worldwide.

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The mature oocytes are put onto a special culture medium and stored in the incubator. Demographic definitions of infertility An inability of those of reproductive age (15-49 years) to become or remain pregnant within five years of exposure to pregnancy. (DHS2) An inability to become pregnant with a live birth, within five years of exposure based upon a consistent union status, lack of contraceptive use, non-lactating and maintaining a desire for a child. (Trends in prevalence4). For example, polycystic ovarian syndrome is when the eggs only partially developed within the ovary and there is an excess of male hormones. Clinical Characterization of 42 Oligospermic or Azoospermic Men with Microdeletion of the AZFc Region of the Y Chromosome, and of 18 Children Conceived via ICSI. (PDF, 606 KB) Human Reproduction, 2002. Advances in assisted reproductive technologies, such as IVF, can offer hope to many couples where treatment is available, although barriers exist in terms of medical coverage and affordability. In one study,  treatment with recombinant HBD1 in asthenozoospermic and leukocytospermic patients who were deficient in HBD1 resulted in improved bactericidal activity and sperm quality, which supports this protein’s role in fertility and its potential role in managing infertility.[28] Other causes Causes of testicular failure also include the following: Granulomatous disease – Leprosy and sarcoidosis may infiltrate the testicle Sickle cell disease – Sickling of cells within the testis leads to microinfarcts Excessive use of alcohol, cigarettes, caffeine, or marijuana Despite a thorough workup, nearly 25% of men have no discernible cause for their infertility. The NICE guidance has more about unexplained infertility.