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It plays a central role in the multiple imbalances and dysfunctions of polycystic ovary syndrome. Blood, urine, and imaging tests can be done to discover why you are having trouble getting pregnant. In some cases, the egg may have matured properly, but the follicle may have failed to burst (or the follicle may have burst without releasing the egg). The search included meta-analyses, randomized controlled trials, clinical trials, and systematic reviews. The drugs are indicated for diseases like corpus luteum insufficiency, anovulational cycles, and normogonadotropic amenorrhea. Unfortunately, clinical examinations, ultrasounds and analyses rarely indicate the reason for the problem and, as such, medical or surgical treatment is infrequent.

Full history taking of both partners usually denotes the underlying problem [17-23], (Appendix 1). Evaluation should be pursued by 6 months of attempted pregnancy in women with a known history of these abnormalities or a history of bleeding between menstrual cycles. It also tests for a luteal phase defect (inadequate level of progesterone). These include advancing maternal age, severe male factor infertility (whereby ICSI can be used to fertilize the egg), and endometriosis, amongst many others. 10 Data Sources: A PubMed search was completed using the key terms infertility, subfertility, treatment, etiology, and diagnosis.

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Affected individuals displayed more severe forms of infertility such as azoospermia and severe oligozoospermia.[27] Other causes[edit] Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as caused by smoking,[28] other xenobiotic DNA damaging agents (such as radiation or chemotherapy)[29] or accumulation of the oxidative DNA damage 8-hydroxy-deoxyguanosine[30] DNA damage reduces fertility in male sperm, as caused by oxidative DNA damage,[31] smoking,[28] other xenobiotic DNA damaging agents (such as drugs or chemotherapy)[32] or other DNA damaging agents including reactive oxygen species, fever or high testicular temperature.[33] The damaged DNA related to infertility manifests itself by the increased susceptibility to denaturation inducible by heat or acid [34] or by the presence of double-strand breaks that can be detected by the TUNEL assay.[35] General factors Diabetes mellitus,[36][37] thyroid disorders,[38] undiagnosed and untreated coeliac disease,[39][40][41][42] adrenal disease[43] Hypothalamic-pituitary factors Hyperprolactinemia Hypopituitarism The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1. They can interfere with implantation or block the fallopian tube, preventing sperm from fertilizing the egg.

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This technique involves an injection of a single healthy sperm directly injected into mature egg. Clinical Characterization of 42 Oligospermic or Azoospermic Men with Microdeletion of the AZFc Region of the Y Chromosome, and of 18 Children Conceived via ICSI. (PDF, 606 KB) Human Reproduction, 2002. No Differences in Outcome after Intracytoplasmic Sperm Injection with Fresh or with Frozen-thawed Epididymal Spermatozoa. (PDF, 66 KB) Human Reproduction, 1999. Abnormal sperm: The sperm may have an unusual shape, making it harder to move and fertilize an egg.

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If your cycles are infrequent or irregular, your doctor will examine you and perform the appropriate testing to discover which problem you may have and present the appropriate treatment options. In many cases, cornual obstruction diagnosed on HSG represents simple cornual spasm. Some systems are lightweight constructions (18 kg) and can withstand a force of 20 N in any position and direction. The laparoscope aids diagnosis or therapeutic interventions with a few small cuts in the abdomen.[1] Laparoscopic surgery, also called minimally invasive surgery (MIS), bandaid surgery, or keyhole surgery, is a modern surgical technique. When it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technology. Partners may become more anxious to conceive, increasing sexual dysfunction.[17] Marital discord often develops, especially when they are under pressure to make medical decisions. They include: Clomifene (Clomid, Serophene): This encourages ovulation in those who ovulate either irregularly or not at all, because of PCOS or another disorder.