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Typical drugs are clomifene, cyclofenil, tamoxifen, and epimestrol among others. Chronic conditions: These include AIDS or cancer. Recombination Between Palindromes P5 and P1 on the HUman Y Chromosome Causes Massive Deletions and Spermatogenic Failure. (PDF, 786 KB) The American Journal of Human Genetics, 2002. As an antiestrogen, CC requires that the patient have some circulating estrogen levels; otherwise, the patient will not respond to the treatment.

A variety of disorders ranging from hormonal disturbances to physical problems, to psychological problems can cause male infertility.  Although many treatment options are now available, in many cases treatment will not work.  In many instances, male infertility is caused by testicular damage resulting in an inability of the testicle to produce sperm.  Once damaged, the testicle will not usually regain its sperm-making capabilities; this aspect of male infertility is analogous to menopause (though not natural like menopause) for women and cannot usually be treated.  Despite medicine�s limited ability to treat male infertility, many successful treatment options are available for its many causes.  Besides testicular damage, the main causes of male infertility are low sperm production and poor sperm quality.   The Causes of Male Infertility Male infertility has many causes--from hormonal imbalances, to physical problems, to psychological and/or behavioral problems.  Moreover, fertility reflects a man�s �overall� health.  Men who live a healthy lifestyle are more likely to produce healthy sperm.  The following list highlights some lifestyle choices that negatively impact male fertility--it is not all-inclusive: · Smoking--significantly decreases both sperm count and sperm cell motility. · Prolonged use of marijuana and other recreational drugs. · Chronic alcohol abuse. · Anabolic steroid use--causes testicular shrinkage and infertility. · Overly intense exercise--produces high levels of adrenal steroid hormones which cause a    testosterone deficiency resulting in infertility. · Inadequate vitamin C and Zinc in the diet. · Tight underwear--increases scrotal temperature which results in decreased sperm production. · Exposure to environmental hazards and toxins such as pesticides, lead, paint, radiation, radioactive   substances, mercury,  benzene, boron, and heavy metals · Malnutrition and anemia. · Excessive stress! Psychic causes are possible in women just like they are in men. While it may be difficult to detect infertility symptoms outright, here are some signs that may point to fertility issues: Irregular periods: The average woman’s cycle is about 28 days long. 6 The initial history should cover menstrual history, timing and frequency of intercourse, previous use of contraception, previous pregnancies and outcomes, pelvic infections, medication use, occupational exposures, substance abuse, alcohol intake, tobacco use, and previous surgery on reproductive organs.

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The medicalization of infertility has unwittingly led to a disregard for the emotional responses that couples experience, which include distress, loss of control, stigmatization, and a disruption in the developmental trajectory of adulthood.[16] Infertility may have psychological effects. ART procedures, such as GIFT, IVF, and ICSI, also can be used in cases of male infertility. Further reading[edit] Fertility: Assessment and Treatment for People with Fertility Problems. Medication. If you have ovulation problems, you may be prescribed drugs such as clomiphene citrate (Clomid, Serophene), gonadotropins (such as Gonal-F, Follistim, Humegon and Pregnyl), or letrozole. Isolated FSH deficiency This is a very rare cause of infertility.

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We recommend immediate evaluation for a couple attempting pregnancy when the woman has a prior history of pelvic infection. At least one open tube is required for IUI, and the sperm abnormality cannot be severe otherwise the sperm will not be able to swim to and fertilize the egg.

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The HSG is usually scheduled between days 6 and 13 of the cycle - after bleeding and before ovulation. There are tests that may tell if you have fertility problems. A defect in any of these sperm structures may result in infertility that will not be detected by semen analysis.[60] Antisperm antibodies cause immune infertility.[23][24] Cystic fibrosis can lead to infertility in men. Compensatory and Obligatory Renal Growth in Rats. (PDF, 1 MB) American Journal of Physiology, 1974. This improves the chances that the embryo will implant at, or attach to, the wall of the uterus. It is often defined as not conceiving after 12 months of regular sexual intercourse without the use of birth control. A subgroup of patients has PCOS with hyperinsulinism, hyperandrogenism associated with acanthosis nigricans, and resistance to CC. [205, 206] This group is amenable to metformin treatment. [207, 208] Metformin improves insulin sensitivity and decreases hepatic gluconeogenesis and, therefore, reduces hyperinsulinism, basal and stimulated LH levels, and free testosterone concentration. It does not induce ovulation, but reduces the production of prolactin by the pituitary.[20] Bromocriptine is only prescribed in cases of overproduction of prolactin (hyperprolactinemia). It is specially oriented for cancer patients, whose sperm is destroyed due to the gonadotoxic treatment they are submitted to.[70] Ovaric stem cells: it is thought that women have a finite number of follicles from the very beginning. PDF Articles by Decade: 1970s | 1980s | 1990s | 2000s | 2010s ARTICLES FROM THE 1970s Active Lupus Glomerulitis and Hematoxylin Bodies with Normal Urinalysis. (PDF, 5 MB) The Journal of Urology, 1971. One type of ovulation problem, polycystic ovarian syndrome, is effectively treated with medications.