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Patients who do not ovulate because of a fault in the pituitary gland may receive this drug as an injection. Affected individuals displayed more severe forms of infertility such as azoospermia and severe oligozoospermia.[27] Other causes[edit] Factors that can cause male as well as female infertility are: DNA damage DNA damage reduces fertility in female ovocytes, as caused by smoking,[28] other xenobiotic DNA damaging agents (such as radiation or chemotherapy)[29] or accumulation of the oxidative DNA damage 8-hydroxy-deoxyguanosine[30] DNA damage reduces fertility in male sperm, as caused by oxidative DNA damage,[31] smoking,[28] other xenobiotic DNA damaging agents (such as drugs or chemotherapy)[32] or other DNA damaging agents including reactive oxygen species, fever or high testicular temperature.[33] The damaged DNA related to infertility manifests itself by the increased susceptibility to denaturation inducible by heat or acid [34] or by the presence of double-strand breaks that can be detected by the TUNEL assay.[35] General factors Diabetes mellitus,[36][37] thyroid disorders,[38] undiagnosed and untreated coeliac disease,[39][40][41][42] adrenal disease[43] Hypothalamic-pituitary factors Hyperprolactinemia Hypopituitarism The presence of anti-thyroid antibodies is associated with an increased risk of unexplained subfertility with an odds ratio of 1. Etiology of Sterility Causes of sterility can be manifold and diverse. The woman may be given a low dose of ovary stimulating hormones. Intracytoplasmic Sperm Injection. (PDF, 4 MB) Chapter 47 from textbook Current Therapy in Equine Reproduction, 2006.

Controversies in OB/GYN: Is Varicocelectomy Useful for Treatment of Male-factor Infertility? (PDF, 4 MB)Contemporary OB/GYN, 2001. Successful Autotransplantation of an Intra-abdominal Testis to the Scrotum by Microvascular Technique. (PDF, 11 MB) The Journal of Urology, 1976.

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Abundant Gene Conversion Between Arms of Palindromes in Human and Ape Y Chromosomes. (PDF, 340 KB)Nature, 2003. Some causes, such as hyperprolactinemia, are reversible with proper treatment. An obstruction can occur anywhere in the plumbing between the testicles and the penis.

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This is called the fulcrum effect.[22] Some surgeries (carpal tunnel for instance) generally turn out better for the patient when the area can be opened up, allowing the surgeon to see "the whole picture" surrounding physiology, to better address the issue at hand. In many instances, patients can ovulate while on metformin treatment. Out of 100 couples in the United States, 12 to 13 have trouble conceiving. The diagnostic charts, which may be photocopied, provide an unambiguous route to diagnosis of the underlying cause of infertility, whilst the text fully explains and describes the essential clinical tests. Mental stress: Stress can be a factor, especially if it leads to reduced sexual activity.

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Testicular Neoplasm in Father and Son. (PDF, 561 KB) The Journal of Urology, 1972. Infertility service use in the United States: data from the National Survey of Family Growth, 1982–2010. 6,23 Anovulatory women should have further investigation to determine treatable causes such as thyroid disorders or hyperprolactinemia based on symptoms. Normal sperm have a smooth oval head approximately 3-5 μm long and 2-3 μm wide. While orchitis develops a few days after the onset of parotid gland inflammation, it may also precede it. Hofherr SE, Wiktor AE, Kipp BR, Dawson DB, Van Dyke DL. Because cyclicity in queens is determined by photoperiod, lighting conditions should be appropriate for several months before congenital anestrus is diagnosed and exogenous hormones are administered. Spermatogonia rest on the basement membrane and contain dense nuclei and prominent nucleoli. These include: non-steroidal anti-inflammatory drugs (NSAIDs) – long-term use or a high dosage of NSAIDs, such as ibuprofen or aspirin, can make it more difficult to conceive chemotherapy – medicines used for chemotherapy can sometimes cause ovarian failure, which means your ovaries will no longer be able to function properly neuroleptic medicines – antipsychotic medicines often used to treat psychosis; they can sometimes cause missed periods or infertility spironolactone – a type of medicine used to treat fluid retention (oedema); fertility should recover around 2 months after you stop taking spironolactone Illegal drugs, such as marijuana and cocaine, can seriously affect fertility and make ovulation more difficult. Most couples (approximately 85%) will achieve pregnancy within one year of trying, with the greatest likelihood of conception occurring during the earlier months. The rising number of obese individuals may be due in part to an energy-rich diet as well as insufficient physical exercise.  In addition to other potential health risks, obesity can have a significant impact on male and female fertility. 6 mg SC q4wk for 6 months) GnRHa therapy can be administered along with cyclic or continuous progestins or with cyclic or continuous estrogen and progestins in cases of severe hot flashes. [145, 152] Combined therapy Medical and surgical treatments are usually combined for the treatment of severe endometriosis. The elevated temperature hinders the maturation process of sperm, which develop best in an environment that is slightly cooler than body temperature.