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Poor egg quality: Eggs that are damaged or develop genetic abnormalities cannot sustain a pregnancy. Careful monitoring during treatment and pregnancy can help reduce the risk of complications. Drugs used for both women and men[67] include clomiphene citrate, human menopausal gonadotropin (hMG), follicle-stimulating hormone (FSH), human chorionic gonadotropin (hCG), gonadotropin-releasing hormone (GnRH) analogues, aromatase inhibitors, and metformin. Unexplained infertility in women or men may be managed with another year of unprotected intercourse, or may proceed to assisted reproductive technologies, such as intrauterine insemination or in vitro fertilization.

Passive smoking has also been linked to lower fertility. Normal uterine implantation can therefore not occur. Medications, treatments, and drugs Some drugs can affect fertility in a woman. This is done for men with very low or no sperm in their semen. Embryo Development after ICSI Using Testicular, Epididymal and Ejaculated Spermatozoa. (PDF, 2 MB) Frontiers in Endocrinology, 1995. Alcohol: Any amount of alcohol consumption can affect the chances of conceiving.

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S. women, or 6% of the married population 15 to 44 years of age, reported infertility, and 6. Fertility Evaluation of the Male Partner: Other Tests Other tests for men include: Urine analysis to rule out an infection. Diverse Spermatogenic Defects in Humans Caused by Y Chromosome Deletions Encompassing a Novel RNA-binding Protein Gene. (PDF, 7 MB) Nature Genetics, 1995. Rarely, a blood clot may develop in an artery or vein, liver or kidney problems can arise, and respiratory distress may develop. In other cases, the cause is suspected to be immunological or genetic; it may be that each partner is independently fertile but the couple cannot conceive together without assistance.

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In some cases, your doctor may recommend a procedure known as intracytoplasmic sperm injection (ICSI). Some methods may be used in concert with other methods. Couples who do not conceive after treatment for six cycles with documented ovulation should also consider referral to an infertility specialist. In men, exposure to lead can reduce both sex drive and sperm count. In ZIFT, your doctor places the fertilized eggs -- at this stage called zygotes -- into your fallopian tubes within 24 hours. Use of clomiphene citrate in infertile women: a committee opinion.

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Overweight or obesity: This may reduce the chance of conceiving. They can also carry out some basic tests on both partners to see if there is an identifiable reason for not having achieved a pregnancy. Usually, you’ll still be able to maintain erections and have sex, and the quantity and appearance of your semen will also be normal. Infertility: Female and Male Factors It is very important to note that infertility can occur as a result of one or more male or female factors. Germ cells interdigitate with the Sertoli cells and undergo ordered maturation, migrating toward the lumen as they mature. ART: Intracytoplasmic Sperm Injection (ICSI) Another ART procedure  Intracytoplasmic Sperm Injection (ICSI)  involves the injection of a single sperm into the egg. Rarely, a blood clot may develop in an artery or vein, liver or kidney problems can arise, and respiratory distress may develop. It has been proven useful in overcoming infertility conditions, such as blocked or damaged tubes, endometriosis, repeated IUI failure, unexplained infertility, poor ovarian reserve, poor or even nil sperm count. Intra-uterine insemination for male subfertility. Testosterone is converted to dihydrotestosterone (DHT) by the action of 5-alpha reductase, both locally and in the periphery, and to estrogen in the periphery. If this is unsuccessful, the dosage may be increased to 100 mg daily. They include: Clomifene (Clomid, Serophene): This encourages ovulation in those who ovulate either irregularly or not at all, because of PCOS or another disorder. Medication. If you have ovulation problems, you may be prescribed drugs such as clomiphene citrate (Clomid, Serophene), gonadotropins (such as Gonal-F, Follistim, Humegon and Pregnyl), or letrozole.